Who Uses Retatrutide
Aggressive Weight Loss
The strongest weight loss compound in trials to date — significant fat loss over the course of a full cycle.
Stalled on GLP-1s
For people who plateaued on Semaglutide or Tirzepatide and need a stronger mechanism to break through.
Metabolic Repair
Improves insulin sensitivity and metabolic markers alongside the weight loss effect.
1
Reconstitution
Vial Size & Water Guide
| Vial Size | Bacteriostatic Water | Concentration | 2mg Dose → Draw To |
|---|---|---|---|
| 10 mg | Add 1 mL | 0.1 mg per unit | 20 units on the syringe |
| 20 mg | Add 2 mL | 0.1 mg per unit | 20 units on the syringe |
Tilt the vial and inject bacteriostatic water slowly down the glass wall. Swirl gently — do not shake. Refrigerate immediately after mixing.
Watch: How to Reconstitute a Peptide Vial
Note: water amounts vary by compound — always follow the reconstitution amounts listed in the table above for Retatrutide.
2
How to Inject
Method
SubQ (Subcutaneous)
Into the fat layer just under the skin
Needle Angle
45°
Pinch skin, insert at a shallow angle
Preferred Sites
Belly, thigh, or upper arm
Rotate sites weekly
Timing
Once per week
Same day every week — consistency is critical
3
Your Protocol
Slow & Steady
4 mg
max weekly (after titration)
Best For
Sensitive individuals, first GLP-1 users, or those who want manageable side effects
Draw at Maintenance
4mg → draw to 40 units
(both vial sizes)
(both vial sizes)
Titration
Wk 1–4: 2mg → Wk 5+: 4mg
Most Popular
Suggested
6 mg
max weekly (after titration)
Best For
Most users — sweet spot for strong fat loss with manageable side effects
Draw at Maintenance
6mg → draw to 60 units
(both vial sizes)
(both vial sizes)
Titration
Wk 1–4: 2mg → Wk 5–8: 4mg → Wk 9+: 6mg
Aggressive but Safe
8–10 mg
max weekly (after full titration)
✓ Well-documented in community — not reckless, maximum therapeutic range
Best For
Experienced users, significant weight loss goals, maximum body composition change
Draw at Maintenance
8mg → 80 units | 10mg → 100 units
(both vial sizes)
(both vial sizes)
Titration
Wk 1–4: 2mg → Wk 5–8: 4mg → Wk 9–12: 6mg → Wk 13+: 8–10mg
Titration Comparison — All 3 Protocols Side by Side (Weekly Dose)
| Week | Slow & Steady | Suggested | Aggressive |
|---|---|---|---|
| Week 1–4 | 2 mg | 2 mg | 2 mg |
| Week 5–8 | 4 mg | 4 mg | 4 mg |
| Week 9–12 | 4 mg | 6 mg | 6 mg |
| Week 13+ | 4 mg | 6 mg | 8–10 mg |
What to Expect
- Week 1–2: Significant appetite reduction. Food cravings drop sharply. Some users experience mild nausea at first — this is normal and passes.
- Week 4–6: Noticeable weight loss begins. Energy may dip slightly as calories decrease — keep protein high.
- Week 12+: Significant body composition change. Combined with adequate protein and exercise, muscle mass is preserved while fat loss accelerates.
Do
- Titrate slowly — do not rush to higher doses
- Stay hydrated — GLP-1 agonists can cause dehydration
- Maintain high protein intake (0.8–1g per lb bodyweight) to preserve muscle
- Keep the same injection day each week
Don't
- Start at a high dose — severe nausea will result
- Skip the titration schedule
- Stop eating entirely — keep calories at a reasonable deficit
- Shake the vial — swirl gently only
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Supplies You'll Need
Insulin Syringes (for injection)
Use one fresh syringe per injection. 29–31 gauge ensures minimal discomfort for SubQ use.
Reconstitution Syringe
For mixing only — do NOT use for injection.
Alcohol Swabs
Wipe the vial top and injection site before every use.