Who Uses MOTS-C
Metabolic Health
Better insulin sensitivity and metabolic flexibility.
Body Composition
Users focused on leaner body composition and fat loss.
Exercise Mimetic
Amplifies the same pathways activated by physical training.
1
Reconstitution
Vial Size & Water Guide
| Vial Size | Bacteriostatic Water | Concentration | 10mg Dose → Draw To |
|---|---|---|---|
| 10 mg | Add 2 mL | 0.05 mg per unit | 200 units (2 syringes) |
Each vial is one injection. MOTS-c is dosed at 10mg per use — one vial = one dose. Tilt the vial at an angle and inject bacteriostatic water slowly down the side — do not aim the stream directly at the powder. Swirl gently until dissolved. Do not shake. Refrigerate immediately after mixing.
Watch: How to Reconstitute a Peptide Vial
Note: water amounts vary by compound — always follow the reconstitution amounts listed in the table above for MOTS-c.
2
How to Inject
Method
SubQ or IM
Subcutaneous (into fat) or intramuscular (into muscle)
Needle Angle
45° SubQ · 90° IM
Pinch skin at 45° for SubQ; straight in at 90° for IM
Preferred Sites
Belly fat (SubQ) or outer thigh (IM)
1–2 inches from navel for SubQ; lateral thigh for IM; rotate sites daily
Timing
Morning, fasted preferred
MOTS-c may be mildly stimulating — morning dosing avoids sleep disruption
3
Your Protocol
Slow & Steady
10 mg
1x per week
Best For
First-time users — maintenance frequency from the start, no loading phase
Draw Amount
10mg vial → draw to 200 units (2 syringes)
Schedule
10mg once per week for the full 8-week cycle
Most Popular
Suggested
10 mg
3x/week → 1x/week (r/Peptides standard)
Best For
Most users — the community standard for noticeable fat loss, energy, and insulin sensitivity improvements
Draw Amount
10mg vial → draw to 200 units (2 syringes)
Schedule
Wks 1–4: 10mg 3x/week → Wks 5–8: 10mg 1x/week
Aggressive but Safe
10 mg
3x/week for 8 wks → 1x/week
✓ Extended loading phase — well-tolerated by the peptide community
Best For
Serious biohackers and experienced users wanting maximum metabolic and longevity effects
Draw Amount
10mg vial → draw to 200 units (2 syringes)
Schedule
Wks 1–8: 10mg 3x/week → Wk 9+: 10mg 1x/week
Frequency Schedule — All 3 Protocols Side by Side (dose is always 10mg)
| Phase | Slow & Steady | Suggested | Aggressive |
|---|---|---|---|
| Weeks 1–4 | 10mg 1x/week | 10mg 3x/week | 10mg 3x/week |
| Weeks 5–8 | 10mg 1x/week | 10mg 1x/week | 10mg 3x/week |
| Week 9+ | 10mg 1x/week | Off (cycle complete) | 10mg 1x/week |
What to Expect
- Weeks 2–3: Energy and metabolic improvements begin. Most users notice better workout output and reduced fatigue during exercise.
- Weeks 4–8: Fat metabolism and insulin sensitivity improve. The metabolic shift becomes more noticeable — especially when paired with consistent training.
- After the cycle: Take 4 weeks off before your next cycle. Effects are cumulative — each cycle builds on the last.
Do
- Inject in the morning — fasted is preferred
- Stay consistent with your injection schedule — frequency matters more than timing
- Pair with exercise — MOTS-c has a strong synergy with physical training
- Refrigerate after reconstitution
Don't
- Inject at night — MOTS-c may be mildly stimulating and could affect sleep
- Expect dramatic visible results — effects are metabolic and systemic, not cosmetic
- Shake the vial — swirl gently only
- Skip the off-cycle — run 8 weeks total (loading + maintenance), then 4 weeks off
↗
Supplies You'll Need
Insulin Syringes (for injection)
Use one fresh syringe per injection. 29–31 gauge ensures minimal discomfort for SubQ or IM use.
Reconstitution Syringe
For mixing only — do NOT use for injection.
Alcohol Swabs
Wipe the vial top and injection site before every use.